Overview

Airtho partnered with a biotechnology manufacturer to design and deliver a compact, high-performance isolator cleanroom that could be integrated into an existing production space. The project required a modular system capable of achieving ISO 6 and ISO 7 cleanliness, efficient recirculation airflow, and precise environmental control—all while fitting around existing equipment and infrastructure.

Challenge

The client needed a fully engineered isolator room within a facility that offered limited overhead space, existing mechanical obstructions, and strict cleanliness requirements. The installation had to support high air-change rates, integrate VRF cooling and makeup air, and maintain proper pressurization—despite the compact footprint and tight coordination zones.

Solution

Airtho engineered a cleanroom system that maximized both performance and constructability:

• High-Efficiency Airflow Design: A combination of Airtho Cell Fan Kits and ducted HEPA filtration provided more than 150 ACH in the isolator area and 30+ ACH in the surrounding zones. The system utilized 2×4 HEPA modules strategically positioned within the Intelligrid™ layout to maintain ISO 6/7 conditions.

• Integrated Cooling & Makeup Air: A 2-ton VRF indoor and outdoor unit supplied conditioned makeup air while supporting room pressurization. Flexible 10" insulated ductwork was used to route air efficiently within the cleanroom footprint.

• Modular Architectural System: The cleanroom enclosure incorporated 4" aluminum-clad wall panels, softwall strip-curtain entries, and a suspended Intelligrid™ ceiling system designed to support HEPA filters, lighting, and blank panels without structural modification to the building.

• Long-Term Serviceability: Airtho provided ongoing support, including a field visit to inspect and restore VRF unit performance by re-leveling the indoor unit, correcting condensate drainage, and verifying airflow after adjustments.

Results

• Stable ISO 6/7 cleanroom performance with high-efficiency airflow

• Seamless integration into an existing production environment

• Compact mechanical design supporting high ACH and positive pressurization

• Modular ceiling and wall system requiring no major building upgrades

• Continued operational reliability supported through responsive field service